In 2011, Ginther et al. first demonstrated that African American and Black applicants to the National Institutes of Health received grant awards at a lower rate than their white counterparts (Ginther 2011). Since then, multiple studies have reproduced and extended this finding (Ginther 2011; Ginther 2016; Hoppe 2019; Erosheva 2020). Recently we reported that African American and Black (AAB) PIs are more likely to propose research on topics that are less likely to be funded (Hoppe 2019). We found that topic choice has little or no effect on whether an application is chosen for discussion, but after considering a number of confounders, it accounts for over 20% of the gap in funding success for applications that are discussed (Hoppe 2019).